Abstract
The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell proliferation (for select analogues) are given.
MeSH terms
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Animals
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Carbamates / chemistry
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Carbamates / pharmacology
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Cell Line
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Cricetinae
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Cricetulus
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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IMP Dehydrogenase / antagonists & inhibitors*
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Inhibitory Concentration 50
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Lymphocyte Activation / drug effects
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Mycophenolic Acid / analogs & derivatives
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Mycophenolic Acid / pharmacology
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Oxazoles / chemical synthesis
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Oxazoles / chemistry*
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Oxazoles / pharmacology*
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Phenylurea Compounds / chemistry
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Phenylurea Compounds / pharmacology
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Structure-Activity Relationship
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T-Lymphocytes / drug effects
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T-Lymphocytes / physiology
Substances
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Carbamates
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Enzyme Inhibitors
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N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester
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Oxazoles
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Phenylurea Compounds
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IMP Dehydrogenase
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Mycophenolic Acid